Barbara obtained her Ph.D. in Biological Chemistry from the University of Michigan, Ann Arbor, where she studied respiratory proteins from Thermus thermophilus under the direction of James A. Fee. She did post-doctoral research on mammalian pyrimidine biosynthetic enzymes in the laboratory of David R. Evans at Wayne State University, Detroit, MI. In 1994, she joined the faculty of the Biochemistry Department of the University of Puerto Rico Medical School, where she initiated research on pyrimidine biosynthesis in the apicomplexan parasite Toxoplasma gondii. She began her current position as associate professor in the Biological Sciences Department of the Universidad de los Andes, in Bogotá, Colombia in the fall of 2004.
E-mail:
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Publications:
Robles Lopez, S. M., Hortua, A., and Zimmermann, B. H. (2006) Cloning and preliminary characterization of the dihydroorotase from Toxoplasma gondii. Molec Biochem Parasitol 148:93-98.
Sierra Pagan, M. L. and Zimmermann, B. H. (2003) Cloning and expression of the dihydroorotate dehydrogenase from Toxoplasma gondii. Biochim Biophys Acta, 1637:178-181.
Mejias-Torres, I. A. and Zimmermann, B. H. (2002) Molecular cloning, recombinant expression, and partial characterization of the aspartate transcarbamoylase from Toxoplasma gondii, Molec Biochem Parasitol 119:191-121.
Meetings:
Hortua Triana, M. A., Loffler, M., Huynh, M.-H., MCarruthers, V. B., Zimmermann, B.H. Kinetic characterization and inhibition of a mitochondrial dihydroorotate dehydrogenase from Toxoplasma gondii, 11th International Congress on Toxoplasmosis, June 25 – 29, 2011. Ottawa, Canada
Rocha, M.C., Camargo, E.A., Lozano, G. L., Primrose, D. M., Zimmermann, B.H. Preliminary kinetic characterizations of recombinant aspartate transcarbamoylase, dihydroorotase and orotate phosphoribosyl transferase from Toxoplasma gondii. 11th International Congress on Toxoplasmosis, June 25 – 29, 2011. Ottawa, Canada
Narváez Ortiz, H. Y., Zimmermann, B.H. Preliminary characterization of the antiparasitic target cytidine triphosphate synthase from Toxoplasma gondii 11th International Congress on Toxoplasmosis, June 25 – 29, Ottawa, Canada
Garavito., M.F., Garcia, L., Lozano., G., Bernal, A., Zimmermann, B.H., Restrepo, S. Dihydroorotate dehydrogenase from the phytopathogenic Oomycete Phytophthora infestans as a novel target for crop control. Congress of the Oomycetes Molecular Genetics Network (OMGN), Toulouse, France. 2010.
Rocha M. C & Zimmermann B. H. Subcloning and expression of recombinant Dihydroorotase of Toxoplasma gondii in the plasmid pET-19b. First steps towards inhibition assays. Molecular Parasitology Meeting XXI, Woods Hole, USA, September 12 – 16, 2010. Poster
Narváez Ortiz, H. Y., Zimmermann, B.H. Preliminary characterization of antiparasitic target Cytidine triphosphate synthase from Toxoplasma gondii, Gordon Research Conference - Enzymes, Coenzymes & Metabolic Pathways, Waterville Valley, New Hampshire, July 18 – 23, 2010.
Hortua Triana, M. A., Loffler, M., Zimmermann, B.H. Kinetic characterization of dihydroorotate dehydrogenase from Toxoplasma gondii. The 22nd International Conference on Arginine and Pyrimidines, Washington D.C.,ICAP 2010, July 22- 25, 2010.
Lozano, G., Zimmermann, B.H. Preliminary studies of Orotate Phosphorybosyltransferase and Orotidine 5’-monophosphate descarboxilase from Toxoplasma gondi. The 22nd International Conference on Arginine and Pyrimidines, Washington D.C., ICAP 2010, July 22- 25, 2010.
Camargo, E.A., Rocha, M.C., Hortua Triana, M.A., Zimmermann, B.H. Subcloning and expression of aspartate transcarbamoylase y dihydroorotase from Toxoplasma gondii: First steps toward inhibition assays. The 22nd International Conference on Arginine and Pyrimidines, Washington D.C., ICAP 2010, July 22- 25, 2010.
Hortua Triana, M. A., Garavito, M.F., Huynh M.-H., Carruthers, V.B., Zimmermann, B. H., Toxoplasma gondii dihydroorotate dehydrogenase and its possible unusual intracellular localization. Kekrade, The Netherlands, 10th International Congress on Toxoplasmosis, June 25 – 29, 2009
Lozano, G., Rocha, M.C., , Zimmermann, B.H. Preliminary studies of Orotate Phosphorybosyltransferase and Orotidine 5’-monophosphate descarboxylase from Toxoplasma gondi. Kekrade, The Netherlands, 10th International Congress on Toxoplasmosis, June 25 – 29, 2009
Garavito, M.F., Becerra, L.F., Campos-Villarraga, J., Chamat, X., Hernández-Roldan, A., Hortua Triana, M.A., Lozano, G.L., Primrose, D.M., Zimmermann, B.H. Selection of epitopes of ROP18 for possible Typification of Toxoplasma gondii. Buzios, Brazil. Toxoplasma Centennial Congress, September 21 – 24, 2008.
Hortua Triana, M. A., Huynh M.-H., Garavito, M.F., Carruthers, Zimmermann, B. H., Didydroorotate dehydrogenase from Toxoplasma gondii and its unusual intracellular localization. International Conference on Arginine and Pyrimidines, London, England. ICAP2008, August 27 – 30, 2008.
Lozano, G., Garavito, M.F. , Zimmermann, B.H. Cloning of Orotate phosphoribosyltransferase from Toxoplasma gondii. International Conference on Arginine and Pyrimidines, London, England. ICAP2008, August 27 – 30, 2008.
Hortua Triana, M. A., Garavito, M.F., Serrano M., and Zimmermann, B.H. Immunolocalization of the pyrimidine biosynthetic enzymes dihydroorotase and dihydroorotate dehydrogenase in tachyzoites of Toxoplasma gondii. 9th International Congress on Toxoplasmosis, Chico Hot Springs, Montana, June 29 – July 2, 2007. Poster.